منابع مشابه
Sgo stabilizes glue and microtubules
Astrocytes orchestrate neuronal synchrony stroctyes are known to modulate synaptic communication between neurons. Now, colleagues report that astrocytes can elicit slow inward currents outside of synapses and thus activate synchronous responses in multiple neurons. During periods of intense neural activity, calcium oscillations are triggered in astrocytes, inducing the cells to release glutamat...
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We have previously shown that DDA3 - also known as proline/serine-rich coiled-coil protein 1 (PSRC1) - is a microtubule-associated protein that promotes cell growth by stimulating the β-catenin pathway. Here, we report that DDA3 can bundle and stabilize microtubules in vivo and in vitro. We found that overexpression of DDA3 increased the abundance of acetylated and tyrosinated microtubules. We ...
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The Cdc14 dual-specificity phosphatases regulate key events in the eukaryotic cell cycle. However, little is known about the function of mammalian CDC14B family members. Here, we demonstrate that subcellular localization of CDC14B protein is cell cycle regulated. CDC14B can bind, bundle, and stabilize microtubules in vitro independently of its catalytic activity. Basic amino acid residues withi...
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BACKGROUND Glomerular podocytes are highly differentiated cells that are key components of the kidney filtration units. The podocyte cytoskeleton builds the basis for the dynamic podocyte cytoarchitecture and plays a central role for proper podocyte function. Recent studies implicate that immunosuppressive agents including the mTOR-inhibitor everolimus have a protective role directly on the sta...
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The spinocerebellar ataxia type 7 (SCA7) gene product, Ataxin-7 (ATXN7), localizes to the nucleus and has been shown to function as a component of the TATA-binding protein-free TAF-containing-SPT3-TAF9-GCN5-acetyltransferase transcription complex, although cytoplasmic localization of ATXN7 in affected neurons of human SCA7 patients has also been detected. Here, we define a physiological functio...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1722iti2